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KMID : 0370220110550060462
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Yakhak Hoeji
2011 Volume.55 No. 6 p.462 ~ p.465
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Synthesis of Chrysin Analogs with a Heteroaryl Group and Evaluation for their Anti-inflammatory Activities
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Che Hai-Yan
Ngoc Tuyen Truong
Kim Hyun-Pyo
Park Hae-Il
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Abstract
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Chrysin analogs with 2-heteroaryl groups were synthesized and evaluated for their inhibitory activities against and NO production from LPS-induced RAW 264.7 cells. Chrysin analogs were synthesized from 2-hydroxy-4,6-dimethoxy-acetophenone and heteroaryl aldehydes in 3 steps. The tested chrysin analogs showed decreased inhibitory activity against and NO production than those of chrysin.
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KEYWORD
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chrysin, 2-heteroaryl, anti-inflammatory, , nitric oxide
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